Chloramphenicol Resistance in Micrococcus Pyogenes
نویسندگان
چکیده
In an earlier report from this laboratory (Wilson and Ramsey, 1955) an antagonism between chloramphenicol and complex materials (yeast extract, proteose peptone #3) was noted. It was suggested that the antagonism observed was possibly due to stimulation of growth, rather than to direct antagonism of the antibiotic. In order to examine more critically the respective roles of stimulation and direct antagonism, experiments have been performed in which the chloramphenicol resistance of cells preincubated in both the presence and the absence of yeast extract was compared with the resistance of cells placed directly in contact with the antibiotic.
منابع مشابه
Chloramphenicol resistance in Micrococcus pyogenes. III. Antagonism of drug action and stimulation of growth by complex substances.
In a previous communication (Ramsey and Padron, 1954) it was noted that Micrococcus pyogenes var. aureus failed to develop resistance to chloramphenicol in a synthetic medium whereas resistant strains were readily obtained by cultivation in complex medium (Bacto-A. C. broth) containing this antibiotic. Further, the resistant strains so isolated showed a wide variation in drug tolerance, their r...
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